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  • 姓  名:方冰
  • 性  别:女
  • 职  称:副教授
  • 所在系别:营养与健康系
  • 办公地点:中国农业大学建大校区1号楼
  • 电子邮箱:bingfang@cau.edu.cn
个人简历

2020.07-至今:中国农业大学,营养与健康系,副教授

2019.04-2020.07:华盛顿州立大学,博士后

2016.03-2019.03:中国农业大学,北京食品营养与人类健康高精尖创新中心,岗位科学家

2013.07-2016.02:国家粮食局科学研究院,助理研究员、副研究员

2008.09-2013.06:中国农业大学,工学博士

2004.09-2008.06:天津大学,工学学士


研究方向

1. 功能因子挖掘(重点糖脂代谢、肠道健康)

2. 生命早期营养干预  

3. 危害因子的内分泌干扰效应

课题项目

1.     企业横向项目“BL99改善便秘功能研究及抑制马拉色菌的益生菌筛选”,204.10万,主持

2.     国家自然科学基金青年基金项目“β-棕榈酸调控肠道干细胞分化的分子机制”,30万,主持

3.     省、市、自治区科技项目“草原酸奶自主优良益生菌种的筛选及应用研究”,20万,主持

4.     中荷奶业发展中心国际合作项目“中国原料乳中耐热芽孢杆菌的区域特性及控制方案研究”,17.5万,主持

5.     北京市科技重大专项“调节血脂代谢营养功能性食品精准制造及应用示范”,25万,子课题主持

6.     中国工程院一般战略咨询项目“食品安全营养健康学科建设战略研究”,59.66万,课题骨干

7.     中国工程院重大战略咨询项目“食品营养与健康战略研究”,300万,课题骨干

8.     北京市教委共建项目“益生菌稳态化技术研究”,220万元,课题骨干

9.     北京市教委共建项目“食品加工品质与安全控制关键技术研究”,400万元,课题骨干

10.  国家重点研发计划“食品安全社会共治信息技术研究与应用示范”,400万元,课题骨干

11.  北京市教委共建项目“食品营养功能品质提升与安全检测技术研究“,520万元,课题骨干

12.  中央级公益性科研院所基本科研业务费专项基金项目“生育酚及甾醇含量对植物油品质的影响”,31万元,主持

13.  粮食公益性行业科研专项任务“食用植物油精炼过程品质变化及科学性评价研究”,218万元,子课题主持

14.  中央级公益性科研院所基本科研业务费专项基金项目“精炼对油脂中微量物质及氧化稳定性影响初探”,15万元,主持


论文著作

一、发表文章

1.       Bing Fang#, Yixuan Li#, Fazheng Ren*. Chiral nanoparticles as adjuvants for vaccines. Chem, 2022, 8: 1-3.

2.       Guo-ping Zhao, Jin-wang Li, Fang-wei Yang, Xue-feng Yin, Fa-zheng Ren, Bing Fang*, Guo-fang Pang*. Spermiogenesis toxicity of imidacloprid in rats, possible role of CYP3A4. Chemosphere, 2021, 282: 131120.

3.       Fang-Wei Yang, Bing Fang*, Guo-Fang Pang, Ming Zhang, Fa-Zheng Ren. Triazophos and its metabolite diethyl phosphate have different effects on endocrine hormones and gut health in rats. Journal of Environmental Science and Health Part B, 2021, 56(6): 1-11.

4.       杨志轩, 方冰*, 任发政, 冷小京. 牛α-乳白蛋白-油酸复合物对肿瘤细胞能量代谢的影响. 中国食品学报, 2021, 21(1): 38-43.

5.       Bing Fang*, Zhi-xuan Yang, Fa-zheng Ren. The self-assembled α-lactalbumin-oleic acid complex inhibits ATP supply from both glycolysis and the TCA cycle in HepG2 cells and HepG2-bearing nude mice. International Journal of Biological Macromolecules, 2020, 159: 258-263.

6.       Sun, Y., Yang, Z., Ren, F.Z., Fang, B*. FGF19 alleviates palmitate-induced atrophy in C2C12 cells by inhibiting mitochondrial overload and insulin resistance. International Journal of Biological Macromolecules, 2020, 158: 401-407.  

7.       Sun, Y., Huang, J., Chen, Z., Du, M., Ren, F.Z., Luo, J.*, Fang, B*. Amyotrophy induced by a high-fat diet is closely related to inflammation and protein degradation determined by quantitative phosphoproteomic analysis in skeletal muscle of C57BL/6J mice. The Journal of Nutrition, 2020, 150(2), 294-302.

8.       方冰*, 董立杰, 任发政, 周晓娟, 葛绍阳. 益生菌骆驼乳粉对II型糖尿病患者的辅助降糖作用. 中国乳品工业, 2020, 48(6): 14-17.

9.       Li, J.W., Fang, B.*, Pang, G.F., Zhang, M., Ren, F.Z. Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. Pesticide Biochemistry and Physiology, 2019, 59, 68-79.

10.    Yang, F.W., Fang, B.*, Pang, G.F., Ren, F.Z. Organophosphorus pesticide triazophos: a new endocrine disruptor chemical of hypothalamus-pituitary- adrenal axis. Pesticide Biochemistry and Physiology, 2019, 59, 91-97.

11.    Li, J.W., Pang, G.F., Ren, F.Z., Fang, B*. Chlorpyrifos-induced reproductive toxicity in rats could be partly relieved under high-fat diet. Chemosphere, 2019, 229, 94-102.

12.    Xing, H.Z., Fang, B.*, Pang, G.F., Ren, F.Z. 3-Monochloropropane-1, 2-diol causes irreversible damage to reproductive ability independent of hormone changes in adult male rats. Food and Chemical Toxicology, 2019, 124, 10-16.

13.    方冰, 张昊, 郭慧媛, 任发政*. 毛细管区带电泳在牛乳蛋白掺假检测中的应用及方法优化. 中国食品学报, 2019, 19(3): 289-298 (EI).

14.    Fang, B.*, Li, J.W., Zhang, M., Ren, F.Z., Pang, G.F*. Chronic chlorpyrifos exposure elicits diet-specific effects on metabolism and the gut microbiome in rats. Food and Chemical Toxicology, 2018, 111, 144-152.

15.    Yang, F.W., Li, J.W., Pang, G.F., Ren, F.Z., Fang, B*. Effects of diethyl phosphate, a non-specific metabolite of organophosphorus pesticides, on serum lipid, hormones, inflammation, and gut microbiota. Molecules, 2019, 24, 2003.

16.    Fang, B.*, Zhang, M., Shan, G.K., Xing, H.Z., Ren, F.Z. α-Lactalbumin-oleic acid complex kills tumor cells by inducing excess energy metabolism but inhibiting mRNA expression of the related enzymes. Journal of Dairy Science, 2018, 101(6), 4853-4863.

17.    Fang, B.*, Zhang, M., Wu, H., Fan, X., Ren, F.Z. Internalization properties of the anti-tumor α-lactalbumin-oleic acid complex. International Journal of Biological Macromolecule, 2017, 96, 44-51.

18.    Fang, B.*, Zhang, M., Shen, Y.M. Importance of the higher retention of tocopherols and sterols for the oxidative stability of soybean and rapeseed oils. Journal of Food Science and Technology, 2017, 54(7), 1938-1944.

19.    方冰*, 王瑛瑶, 周晓丹, 任发政. 以秀丽隐杆线虫评价植物油膳食对机体寿命的影响. 中国食品学报, 2017, 17(6), 225-231 (EI).

20.    方冰, 栾霞, 李晓宁, 王莹辉. 利用主成分回归分析法建立微量成分与菜籽油烟点间的预测方程. 中国粮油学报, 2017, 32(4), 127-132.

21.    Fang, B.*, Zhang, M., Fan, X., Ren, F.Z. The targeted proteins in tumor cells treated with the α-lactalbumin-oleic acid complex examined by descriptive and quantitative liquid chromatography-tandem mass spectrometry. Journal of Dairy Science, 2016, 99(8), 5991-6004.

22.    Fang, B.*, Zhang, M., Ren, F.Z., Zhou, X.D. Lifelong diet including common unsaturated fatty acids extends the lifespan and affects oxidation in Caenorhabditis elegans consistently with hormesis model  European Journal of Lipid Science and Technology, 2016, 118(7), 1084-1092.

23.    Wu, Y., Fang, B.*, Wu, H., Zhang, M., Shen, Y. Establishment of mathematical relationships between smoke point and minor compounds in vegetable oils using principal component regression analysis. Chemical Engineering transactions, 2016, 51, 1153-1158 (EI).  

24.    方冰, 王瑛瑶, 栾霞, 王莹辉, 朱宁科, 杨宁. 生育酚及甾醇含量对大豆油氧化稳定性及贮藏稳定性的影响. 中国粮油学报, 2016, 31(11), 69-73.

25.    方冰, 朱宁科, 王瑛瑶, 栾霞. 大豆油和菜籽油中游离脂肪酸与烟点的数学关系研究. 中国粮油学报, 2016, 31(10), 56-59.          

26.    Fang, B., Zhang, M., Tian, M., Ren, F.Z*. Self-assembled β-lactoglobulin–oleic acid and β-lactoglobulin–linoleic acid complexes with anti-tumor activities. Journal of Dairy Science, 2015, 98(5), 2898-2907.

27.    Fang, B., Zhang, M., Tian, M., Jiang, L., Ren, F.Z*. Bovine lactoferrin binds oleic acid to form an anti-tumor complex similar to HAMLET. Biochimica et Biophysica Acta- Molecular and Cell Biology of Lipids, 2014, 1841(4), 535-543.

28.    Fang, B., Guo, H.Y., Zhang, M., Jiang, L., Ren, F.Z*. The six amino acid antimicrobial peptide bLFcin6 penetrates cells and delivers siRNA. FEBS Journal, 2013, 280(4), 1007-1017.

29.    Fang, B., Jiang, L., Zhang, M., Ren, F.Z*. A novel cell-penetrating peptide TAT-A1 delivers siRNA into tumor cells selectively.      Biochimie, 2013, 95(2), 251-257.

30.    Fang, B., Zhang, M., Jiang, L., Jing, H., Ren, F.Z*. Influence of pH on the structure and oleic acid binding ability of bovine α-lactalbumin. Protein Journal, 2012, 31, 564-572.

31.    Fang, B., Jiang, L., Ren, F.Z*. Effects of initial heating temperature on the crystallization rate of trans-free palm oil. Journal of Thermal Analysis and Calorimetry, 2010, 100(3), 1085-1090.


二、授权专利

1. 任发政, 方冰, 王鹏杰, 张明, 郭慧媛, 张昊. 一种含有乳蛋白和脂肪酸的组合物及其制备方法与应用. ZL 201210256596.2

2. 任发政, 方冰, 张明, 郭慧媛, 姜鹭. 穿膜肽和药物组合物及其制备方法和应用. ZL 201210533650.3

3. 任发政, 方冰, 张明, 郭慧媛, 姜鹭. 一种穿膜肽和药物组合物及其制备方法和应用. ZL 201210579238.5

4. 庞国芳, 陈谊, 范春林, 邹小波, 孙悦红, 常巧英, 侯堃, 方冰. 基于高分辨质谱、互联网和数据科学的农药残留侦测数据平台及侦测报告自动生成方法.ZL 201710249874.4      

5. 庞国芳, 庞小平, 邹小波, 范春林, 任福, 常巧英, 刘海燕, 方冰. 基于高分辨质谱+互联网+地理信息的农药残留可视方法. ZL 201710250785.1


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